MMP12
Functional Attributes in Pathways
-
Substrates : 153 entries in CutDB for M10.009
Ext
-
alpha1-proteinase inhibitor (Homo sapiens)
-
apolipoprotein A-I preproprotein
-
biglycan preproprotein
-
CD14 antigen
-
clusterin isoform 1
-
clusterin isoform 2
-
Coagulation factor XII precursor
-
collagen type III alpha 1 preproprotein
-
collagen, type II, alpha 1 isoform 1 precursor
-
collagen, type II, alpha 1 isoform 2 precursor
-
decorin isoform a preproprotein
-
Elastin precursor
-
fibrillin 1
-
fibrillin 2 precursor
-
fibrinogen, alpha chain isoform alpha preproprotein
-
fibrinogen, alpha polypeptide isoform alpha-E preproprotein
-
fibromodulin precursor
-
fibronectin 1 isoform 1 preproprotein
-
fibronectin 1 isoform 2 preproprotein
-
fibronectin 1 isoform 3 preproprotein
-
fibronectin 1 isoform 4 preproprotein
-
fibronectin 1 isoform 5 preproprotein
-
fibronectin 1 isoform 6 preproprotein
-
fibronectin 1 isoform 7 preproprotein
-
Golli-mbp isoform 1
-
Golli-mbp isoform 2
-
IgG1 heavy chain (hinge region)
-
laminin, gamma 2
-
Lipoprotein, lp(a)
-
myelin basic protein isoform 1
-
myelin basic protein isoform 2
-
myelin basic protein isoform 3
-
myelin basic protein isoform 4
-
plasminogen activator, urokinase receptor
-
Plasminogen activator, urokinase receptor isoform 1 precursor
-
plasminogen activator, urokinase receptor isoform 1 precursor
-
proline arginine-rich end leucine-rich repeat protein precursor
-
Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) isoform a
-
Substrate Specificity -- Under development
-
Inhibitors -- Under development
-
Pathways -- Under development
Recent News and Literature
- The interaction of monocytes...Immunology. 2008 Nov 14.
- Immunohistochemical study of lung...J Bras Pneumol. 2008 Oct;34(10):787-95.
- No Association of MMP-7,...Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2514-8.
- Inactivation of N-TIMP-1 by N-terminal...Biopolymers. 2008 Nov;89(11):960-8.
- Serotonin regulates macrophage-mediated angiogenesis...Cancer Res. 2008 Jul 1;68(13):5152-8.
- Alveolar macrophage activation and an emphysema-like...Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1035-42. Epub 2008 Mar 7.
- Bone marrow stromal cells...Int J Cancer. 2008 Mar 6;.
- Additional MDA-MB-231 breast cancer...J Cell Physiol. 2008 Aug;216(2):480-5.
- Matrix metalloproteinase single-nucleotide polymorphisms...Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6673-80.
- An integrated high-performance liquid...J Chromatogr A. 2008 May 2;1189(1-2):417-25. Epub 2007 Oct 25.
- EGCG inhibits growth, invasion,...Front Biosci. 2008 Jan 1;13:440-52.
- BeWo cells stimulate smooth...Hum Reprod. 2007 Nov;22(11):2834-41. Epub 2007 Sep 27.
- Biological effects of particles...Chem Res Toxicol. 2007 Oct;20(10):1426-33. Epub 2007 Sep 21.
- Involvement of specific matrix...Mol Cancer Ther. 2007 Sep;6(9):2563-71.
- Functional modulation of Crohn's...Gastroenterology. 2007 Jul;133(1):137-49. Epub 2007 May 5.
- Clinical implications of matrix...J Gastroenterol Hepatol. 2007 Jul;22(7):1064-70.
- Platinum complexes can inhibit...J Med Chem. 2007 Jul 26;50(15):3434-41. Epub 2007 Jun 21.
- Increased expression of human...Pathol Res Pract. 2007;203(7):499-505. Epub 2007 Jun 14.
- Prognostic values of matrix...J Surg Res. 2008 May 1;146(1):32-42. Epub 2007 May 31.
- A new methodology for monitoring...J Am Soc Mass Spectrom. 2007 May;18(5):961-9. Epub 2007 Mar 23.
Structural Features
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLD
TSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADIL
VVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNL
ISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQY
WRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Cross annotation in other databases
MMP12 in:
Gene Cards
- Diseases
- Expression
- SNP
- Drugs
Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS
Functional Attributes in Pathways
-
Substrates : 153 entries in CutDB for M10.009
Ext
- alpha1-proteinase inhibitor (Homo sapiens)
- apolipoprotein A-I preproprotein
- biglycan preproprotein
- CD14 antigen
- clusterin isoform 1
- clusterin isoform 2
- Coagulation factor XII precursor
- collagen type III alpha 1 preproprotein
- collagen, type II, alpha 1 isoform 1 precursor
- collagen, type II, alpha 1 isoform 2 precursor
- decorin isoform a preproprotein
- Elastin precursor
- fibrillin 1
- fibrillin 2 precursor
- fibrinogen, alpha chain isoform alpha preproprotein
- fibrinogen, alpha polypeptide isoform alpha-E preproprotein
- fibromodulin precursor
- fibronectin 1 isoform 1 preproprotein
- fibronectin 1 isoform 2 preproprotein
- fibronectin 1 isoform 3 preproprotein
- fibronectin 1 isoform 4 preproprotein
- fibronectin 1 isoform 5 preproprotein
- fibronectin 1 isoform 6 preproprotein
- fibronectin 1 isoform 7 preproprotein
- Golli-mbp isoform 1
- Golli-mbp isoform 2
- IgG1 heavy chain (hinge region)
- laminin, gamma 2
- Lipoprotein, lp(a)
- myelin basic protein isoform 1
- myelin basic protein isoform 2
- myelin basic protein isoform 3
- myelin basic protein isoform 4
- plasminogen activator, urokinase receptor
- Plasminogen activator, urokinase receptor isoform 1 precursor
- plasminogen activator, urokinase receptor isoform 1 precursor
- proline arginine-rich end leucine-rich repeat protein precursor
- Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) isoform a
- Substrate Specificity -- Under development
- Inhibitors -- Under development
- Pathways -- Under development
Recent News and Literature
- The interaction of monocytes...Immunology. 2008 Nov 14.
- Immunohistochemical study of lung...J Bras Pneumol. 2008 Oct;34(10):787-95.
- No Association of MMP-7,...Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2514-8.
- Inactivation of N-TIMP-1 by N-terminal...Biopolymers. 2008 Nov;89(11):960-8.
- Serotonin regulates macrophage-mediated angiogenesis...Cancer Res. 2008 Jul 1;68(13):5152-8.
- Alveolar macrophage activation and an emphysema-like...Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1035-42. Epub 2008 Mar 7.
- Bone marrow stromal cells...Int J Cancer. 2008 Mar 6;.
- Additional MDA-MB-231 breast cancer...J Cell Physiol. 2008 Aug;216(2):480-5.
- Matrix metalloproteinase single-nucleotide polymorphisms...Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6673-80.
- An integrated high-performance liquid...J Chromatogr A. 2008 May 2;1189(1-2):417-25. Epub 2007 Oct 25.
- EGCG inhibits growth, invasion,...Front Biosci. 2008 Jan 1;13:440-52.
- BeWo cells stimulate smooth...Hum Reprod. 2007 Nov;22(11):2834-41. Epub 2007 Sep 27.
- Biological effects of particles...Chem Res Toxicol. 2007 Oct;20(10):1426-33. Epub 2007 Sep 21.
- Involvement of specific matrix...Mol Cancer Ther. 2007 Sep;6(9):2563-71.
- Functional modulation of Crohn's...Gastroenterology. 2007 Jul;133(1):137-49. Epub 2007 May 5.
- Clinical implications of matrix...J Gastroenterol Hepatol. 2007 Jul;22(7):1064-70.
- Platinum complexes can inhibit...J Med Chem. 2007 Jul 26;50(15):3434-41. Epub 2007 Jun 21.
- Increased expression of human...Pathol Res Pract. 2007;203(7):499-505. Epub 2007 Jun 14.
- Prognostic values of matrix...J Surg Res. 2008 May 1;146(1):32-42. Epub 2007 May 31.
- A new methodology for monitoring...J Am Soc Mass Spectrom. 2007 May;18(5):961-9. Epub 2007 Mar 23.
Structural Features
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLD
TSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADIL
VVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNL
ISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQY
WRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Cross annotation in other databases
MMP12 in:
- Gene Cards
- Diseases
- Expression
- SNP
- Drugs
- Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS

