MMP14
Functional Attributes in Pathways
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Substrates : 185 entries in CutDB for M10.014
Ext
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Aggrecan 1 isoform 2 precursor
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alpha 1 type I collagen preproprotein
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alpha 1 type II collagen isoform 1
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alpha 1 type XVIII collagen isoform 1 precursor
-
alpha 2 type I collagen
-
alpha-1-microglobulin/bikunin precursor
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Alpha-2-HS-glycoprotein precursor
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alpha-2-macroglobulin precursor
-
amyloid beta A4 protein precursor, isoform a
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apolipoprotein A-I preproprotein
-
apolipoprotein A-IV precursor
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apolipoprotein C-II precursor
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apolipoprotein E precursor
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apolipoprotein J
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autoantigen La
-
basigin isoform 1 precursor
-
beta-2-microglobulin precursor
-
beta-galactoside-binding lectin precursor
-
cadherin 1
-
cadherin 1, type 1 preproprotein
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cathepsin A isoform a precursor
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cathepsin A isoform b precursor
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cathepsin B preproprotein
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CD44 antigen isoform 1 precursor
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chemokine (C-C motif) ligand 7 precursor
-
Coagulation factor XII precursor
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complement component 1, q subcomponent binding protein precursor
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complement component 3 precursor
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complement component 4B preproprotein
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connective tissue growth factor
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cysteine-rich motor neuron 1
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cysteine-rich, angiogenic inducer, 61
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dickkopf homolog 1 precursor
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EGF-containing fibulin-like extracellular matrix protein 1 precursor
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elafin preproprotein
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enolase 2
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epididymal secretory protein E1 precursor
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extracellular matrix protein 1 isoform 1 precursor
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extracellular matrix protein 1 isoform 2 precursor
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fibrillin 1 precursor
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fibrinogen, alpha chain isoform alpha preproprotein
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fibrinogen, alpha polypeptide isoform alpha-E preproprotein
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fibrinogen, beta chain preproprotein
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fibrinogen, gamma chain isoform gamma-A precursor
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fibrinogen, gamma chain isoform gamma-B precursor
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fibronectin 1 isoform 1 preproprotein
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FK506-binding protein 1A
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follistatin-like 3 glycoprotein precursor
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Galectin 3
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galectin 3 binding protein
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gelsolin-like capping protein
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Golli-mbp isoform 1
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Golli-mbp isoform 2
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granulin precursor
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growth differentiation factor 15
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heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
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iduronate-2-sulfatase isoform a precursor
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insulin-like growth factor binding protein 4
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insulin-like growth factor binding protein 7
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integrin alpha-V precursor
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inter-alpha (globulin) inhibitor H4
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interleukin 8 precursor
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KIAA1392 protein
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Kiss-1 metastasis-suppressor
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laminin alpha 5
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laminin subunit beta 3 precursor
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laminin, gamma 2 isoform b precursor
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legumain preproprotein
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lumican
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macrophage migration inhibitory factor (glycosylation-inhibiting factor)
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mannose binding lectin 1, protein A
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matrix metalloproteinase 13 preproprotein
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matrix metalloproteinase 14 preproprotein
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Matrix metalloproteinase 2 preproprotein
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matrix metalloproteinase 2 preproprotein
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membrane-type matrix metallopeptidase-1
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Monocyte chemoattractant protein (mcp-3)
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myelin basic protein isoform 1
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myelin basic protein isoform 2
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myelin basic protein isoform 3
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myelin basic protein isoform 4
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Parkinson disease protein 7
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pentraxin 3
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peptidylprolyl isomerase A (cyclophilin A)
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peptidylprolyl isomerase B (cyclophilin B)
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pericentrin (kendrin)
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peroxidasin homolog
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Plasma gelsolin
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proprotein convertase subtilisin/kexin type 9 preproprotein
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protease, serine, 23 precursor
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quiescin Q6 sulfhydryl oxidase 1 isoform a
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quiescin Q6 sulfhydryl oxidase 1 isoform b
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secretory leukocyte peptidase inhibitor precursor
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serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
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serine protease inhibitor, Kunitz type, 2
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soluble mannose-binding lectin precursor
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stanniocalcin 1 precursor
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syndecan 1 precursor
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thrombospondin 1 precursor
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transglutaminase 2 isoform b
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tumor necrosis factor alpha
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vitronectin precursor
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WNT1 inducible signaling pathway protein 2 precursor
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Substrate Specificity for MMP14
-
Inhibitors -- Under development
-
Pathways -- Under development
Recent News and Literature
- Aberrant activation of hedgehog...Carcinogenesis. 2008 Nov 20.
- Polarized MT1-MMP-CD44 interaction and CD44...Cell Motil Cytoskeleton. 2008 Nov 20.
- Overexpression of MT1-MMP is insufficient...Int J Mol Med. 2008 Dec;22(6):757-761.
- Membrane type 1 matrix...Cancer Res. 2008 Nov 15;68(22):9558-65.
- Direct visualization of protease...Matrix Biol. 2008 Oct 29.
- SCCRO (DCUN1D1) Induces Extracellular...Clin Cancer Res. 2008 Nov 1;14(21):6780-9.
- Activation of Matrix Metalloproteinase-2...Cancer Res. 2008 Nov 1;68(21):9096-104.
- Characterization of the transcriptional...Nephrol Dial Transplant. 2008 Oct 16.
- [Expression of MT1-MMP and its significance...Zhonghua Wai Ke Za Zhi. 2008 Apr 15;46(8):606-9.
- Secretion of active membrane...J Cell Biochem. 2008 Sep 18.
- Antitumor activity of a membrane...Mol Cancer Ther. 2008 Sep;7(9):2933-40.
- TLR ligand-induced podosome disassembly...J Cell Biol. 2008 Sep 1.
- HRCT and histopathological evaluation...Respir Med. 2008 Dec;102(12):1753-61. Epub 2008 Aug 23.
- Novel pathway compendium analysis...Bioinformatics. 2008 Oct 15;24(20):2384-90. Epub 2008 Aug 21.
- [Effect of bone morphogenetic...Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Jul;33(7):634-7.
- MT1-MMP regulates urothelial cell...Br J Cancer. 2008 Jul 29.
- A Large-Scale Study of MT1-MMP...Ann Surg Oncol. 2008 Jul 26.
- Impaired tyrosine phosphorylation of membrane-type...Carcinogenesis. 2008 Jul 10.
- Diverse roles of matrix...Neuroscience. 2008 Jun 19;.
- Mapping proteolytic cancer cell-extracellular...Clin Exp Metastasis. 2008 Jul 4.
Structural Features
MSPAPRPSRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKA
DADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFR
EVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICD
GNFDTVAMLRGEMFVFKKRWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYP
KHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVF
FFRRHGTPRRLLYCQRSLLDKV
Cross annotation in other databases
MMP14 in:
Gene Cards
- Diseases
- Expression
- SNP
- Drugs
Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS
Functional Attributes in Pathways
-
Substrates : 185 entries in CutDB for M10.014
Ext
- Aggrecan 1 isoform 2 precursor
- alpha 1 type I collagen preproprotein
- alpha 1 type II collagen isoform 1
- alpha 1 type XVIII collagen isoform 1 precursor
- alpha 2 type I collagen
- alpha-1-microglobulin/bikunin precursor
- Alpha-2-HS-glycoprotein precursor
- alpha-2-macroglobulin precursor
- amyloid beta A4 protein precursor, isoform a
- apolipoprotein A-I preproprotein
- apolipoprotein A-IV precursor
- apolipoprotein C-II precursor
- apolipoprotein E precursor
- apolipoprotein J
- autoantigen La
- basigin isoform 1 precursor
- beta-2-microglobulin precursor
- beta-galactoside-binding lectin precursor
- cadherin 1
- cadherin 1, type 1 preproprotein
- cathepsin A isoform a precursor
- cathepsin A isoform b precursor
- cathepsin B preproprotein
- CD44 antigen isoform 1 precursor
- chemokine (C-C motif) ligand 7 precursor
- Coagulation factor XII precursor
- complement component 1, q subcomponent binding protein precursor
- complement component 3 precursor
- complement component 4B preproprotein
- connective tissue growth factor
- cysteine-rich motor neuron 1
- cysteine-rich, angiogenic inducer, 61
- dickkopf homolog 1 precursor
- EGF-containing fibulin-like extracellular matrix protein 1 precursor
- elafin preproprotein
- enolase 2
- epididymal secretory protein E1 precursor
- extracellular matrix protein 1 isoform 1 precursor
- extracellular matrix protein 1 isoform 2 precursor
- fibrillin 1 precursor
- fibrinogen, alpha chain isoform alpha preproprotein
- fibrinogen, alpha polypeptide isoform alpha-E preproprotein
- fibrinogen, beta chain preproprotein
- fibrinogen, gamma chain isoform gamma-A precursor
- fibrinogen, gamma chain isoform gamma-B precursor
- fibronectin 1 isoform 1 preproprotein
- FK506-binding protein 1A
- follistatin-like 3 glycoprotein precursor
- Galectin 3
- galectin 3 binding protein
- gelsolin-like capping protein
- Golli-mbp isoform 1
- Golli-mbp isoform 2
- granulin precursor
- growth differentiation factor 15
- heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
- iduronate-2-sulfatase isoform a precursor
- insulin-like growth factor binding protein 4
- insulin-like growth factor binding protein 7
- integrin alpha-V precursor
- inter-alpha (globulin) inhibitor H4
- interleukin 8 precursor
- KIAA1392 protein
- Kiss-1 metastasis-suppressor
- laminin alpha 5
- laminin subunit beta 3 precursor
- laminin, gamma 2 isoform b precursor
- legumain preproprotein
- lumican
- macrophage migration inhibitory factor (glycosylation-inhibiting factor)
- mannose binding lectin 1, protein A
- matrix metalloproteinase 13 preproprotein
- matrix metalloproteinase 14 preproprotein
- Matrix metalloproteinase 2 preproprotein
- matrix metalloproteinase 2 preproprotein
- membrane-type matrix metallopeptidase-1
- Monocyte chemoattractant protein (mcp-3)
- myelin basic protein isoform 1
- myelin basic protein isoform 2
- myelin basic protein isoform 3
- myelin basic protein isoform 4
- Parkinson disease protein 7
- pentraxin 3
- peptidylprolyl isomerase A (cyclophilin A)
- peptidylprolyl isomerase B (cyclophilin B)
- pericentrin (kendrin)
- peroxidasin homolog
- Plasma gelsolin
- proprotein convertase subtilisin/kexin type 9 preproprotein
- protease, serine, 23 precursor
- quiescin Q6 sulfhydryl oxidase 1 isoform a
- quiescin Q6 sulfhydryl oxidase 1 isoform b
- secretory leukocyte peptidase inhibitor precursor
- serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
- serine protease inhibitor, Kunitz type, 2
- soluble mannose-binding lectin precursor
- stanniocalcin 1 precursor
- syndecan 1 precursor
- thrombospondin 1 precursor
- transglutaminase 2 isoform b
- tumor necrosis factor alpha
- vitronectin precursor
- WNT1 inducible signaling pathway protein 2 precursor
- Substrate Specificity for MMP14
- Inhibitors -- Under development
- Pathways -- Under development
Recent News and Literature
- Aberrant activation of hedgehog...Carcinogenesis. 2008 Nov 20.
- Polarized MT1-MMP-CD44 interaction and CD44...Cell Motil Cytoskeleton. 2008 Nov 20.
- Overexpression of MT1-MMP is insufficient...Int J Mol Med. 2008 Dec;22(6):757-761.
- Membrane type 1 matrix...Cancer Res. 2008 Nov 15;68(22):9558-65.
- Direct visualization of protease...Matrix Biol. 2008 Oct 29.
- SCCRO (DCUN1D1) Induces Extracellular...Clin Cancer Res. 2008 Nov 1;14(21):6780-9.
- Activation of Matrix Metalloproteinase-2...Cancer Res. 2008 Nov 1;68(21):9096-104.
- Characterization of the transcriptional...Nephrol Dial Transplant. 2008 Oct 16.
- [Expression of MT1-MMP and its significance...Zhonghua Wai Ke Za Zhi. 2008 Apr 15;46(8):606-9.
- Secretion of active membrane...J Cell Biochem. 2008 Sep 18.
- Antitumor activity of a membrane...Mol Cancer Ther. 2008 Sep;7(9):2933-40.
- TLR ligand-induced podosome disassembly...J Cell Biol. 2008 Sep 1.
- HRCT and histopathological evaluation...Respir Med. 2008 Dec;102(12):1753-61. Epub 2008 Aug 23.
- Novel pathway compendium analysis...Bioinformatics. 2008 Oct 15;24(20):2384-90. Epub 2008 Aug 21.
- [Effect of bone morphogenetic...Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Jul;33(7):634-7.
- MT1-MMP regulates urothelial cell...Br J Cancer. 2008 Jul 29.
- A Large-Scale Study of MT1-MMP...Ann Surg Oncol. 2008 Jul 26.
- Impaired tyrosine phosphorylation of membrane-type...Carcinogenesis. 2008 Jul 10.
- Diverse roles of matrix...Neuroscience. 2008 Jun 19;.
- Mapping proteolytic cancer cell-extracellular...Clin Exp Metastasis. 2008 Jul 4.
Structural Features
MSPAPRPSRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKA
DADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFR
EVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICD
GNFDTVAMLRGEMFVFKKRWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYP
KHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVF
FFRRHGTPRRLLYCQRSLLDKV
Cross annotation in other databases
MMP14 in:
- Gene Cards
- Diseases
- Expression
- SNP
- Drugs
- Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS

