cathepsin D
Functional Attributes in Pathways
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Substrates : 141 entries in CutDB for A01.009
Ext
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alpha 1 globin
-
alpha 3 type IV collagen isoform 1 precursor
-
alpha 3 type IV collagen isoform 2 precursor
-
alpha 3 type IV collagen isoform 4 precursor
-
Amyloid beta a4 protein precursor, isoform a
-
beta globin
-
beta-amyloid A4
-
caspase 8 isoform A precursor
-
caspase 8 isoform B precursor
-
caspase 8 isoform C precursor
-
caspase 8 isoform G precursor
-
cathelicidin antimicrobial peptide
-
cathepsin D preproprotein
-
chemokine (C-C motif) ligand 20
-
chemokine (C-C motif) ligand 3
-
chemokine C-C motif ligand 4 isoform 1 precursor
-
Cystatin c precursor
-
dermcidin preproprotein
-
eledoisin
-
fibrin Aalpha chain (Homo sapiens)
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fibroblast growth factor 1 (acidic)
-
fibroblast growth factor 2 (basic)
-
Golli-mbp isoform 1
-
Golli-mbp isoform 2
-
hemoglobin alpha chain
-
hemoglobin alpha chain (Bos taurus)
-
Hemoglobin subunit beta
-
insulin-like growth factor binding protein 3 isoform a precursor
-
insulin-like growth factor binding protein 3 isoform b precursor
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Insulin-like growth factor binding protein 3 isoform b precursor
-
Insulin-like growth factor binding protein 4 precursor
-
insulin-like growth factor binding protein 4 precursor
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kassinin
-
microtubule-associated protein 2
-
myelin basic protein
-
myelin basic protein isoform 1
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myelin basic protein isoform 2
-
myelin basic protein isoform 3
-
myelin basic protein isoform 4
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Osteocalcin
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parathyroid hormone
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plasminogen
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Proinsulin precursor
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prolactin
-
proopiomelanocortin preproprotein
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Small inducible cytokine a21 precursor
-
small inducible cytokine A27 precursor
-
tachykinin 1 isoform alpha precursor
-
tachykinin 1 isoform beta precursor
-
tachykinin 1 isoform delta precursor
-
tachykinin 1 isoform gamma precursor
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Thyroglobulin
-
thyroglobulin
-
Substrate Specificity -- Under development
-
Inhibitors -- Under development
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Pathways -- Under development
Recent News and Literature
- Unbiased Screening for Transcriptional...J Biol Chem. 2008 Dec 12;283(50):35295-304. Epub 2008 Oct 21.
- Leukocyte Elastase Inhibitor, the precursor...Biochim Biophys Acta. 2008 Jul 8.
- CHEMOTHERAPY DRUG RESPONSE IN OVARIAN...J Cell Mol Med. 2008 Jul 24.
- Gene expression analysis of a porcine...Surgery. 2008 Aug;144(2):252-8.
- [Activity of cathepsin D in the blood...Pol Arch Med Wewn. 2006 Dec;116(6):1150-4.
- Cathepsin D and carcino-embryonic...Hepatogastroenterology. 2008 Mar-Apr;55(82-83):388-93.
- Matrix metalloproteinase-9 interplays with...Glia. 2008 Jun 18;.
- Thrombin up-regulates cathepsin D which...Cancer Res. 2008 Jun 15;68(12):4666-73.
- HCCS1 overexpression induces apoptosis...Cell Death Differ. 2008 May 30;.
- Cathepsin D overexpressed by cancer...Adv Exp Med Biol. 2008;617:453-61.
- Estrogen-regulated cut-off values of pS2 and cathepsin...Adv Exp Med Biol. 2008;617:341-8.
- IFN-gamma regulation of vacuolar...J Cell Biochem. 2008 May 20;.
- 2-DE analysis of breast...Oncol Rep. 2008 May;19(5):1237-44.
- Zinc and 4-hydroxy-2-nonenal mediate...J Neurosci. 2008 Mar 19;28(12):3114-22.
- Basement membrane derived fibulin-1...Exp Biol Med (Maywood). 2008 Feb;233(2):155-62.
- American Society of Clinical...J Clin Oncol. 2007 Nov 20;25(33):5287-312. Epub 2007 Oct 22.
- A novel cell penetrating...Biochem Biophys Res Commun. 2007 Dec 14;364(2):243-9. Epub 2007 Oct 4.
- Truncation of annexin A1 is a regulatory...J Biol Chem. 2007 Dec 7;282(49):35679-86. Epub 2007 Oct 10.
- Expression of E-cadherin, beta-catenin,...Chin Med J (Engl). 2007 Sep 20;120(18):1597-605.
- The role of S100P...Cancer Res. 2007 Sep 15;67(18):8633-42.
Structural Features
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYY
GEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPC
QSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPL
IQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRD
NNRVGFAEAARL
Cross annotation in other databases
cathepsin D in:
Gene Cards
- Diseases
- Expression
- SNP
- Drugs
Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS
Functional Attributes in Pathways
-
Substrates : 141 entries in CutDB for A01.009
Ext
- alpha 1 globin
- alpha 3 type IV collagen isoform 1 precursor
- alpha 3 type IV collagen isoform 2 precursor
- alpha 3 type IV collagen isoform 4 precursor
- Amyloid beta a4 protein precursor, isoform a
- beta globin
- beta-amyloid A4
- caspase 8 isoform A precursor
- caspase 8 isoform B precursor
- caspase 8 isoform C precursor
- caspase 8 isoform G precursor
- cathelicidin antimicrobial peptide
- cathepsin D preproprotein
- chemokine (C-C motif) ligand 20
- chemokine (C-C motif) ligand 3
- chemokine C-C motif ligand 4 isoform 1 precursor
- Cystatin c precursor
- dermcidin preproprotein
- eledoisin
- fibrin Aalpha chain (Homo sapiens)
- fibroblast growth factor 1 (acidic)
- fibroblast growth factor 2 (basic)
- Golli-mbp isoform 1
- Golli-mbp isoform 2
- hemoglobin alpha chain
- hemoglobin alpha chain (Bos taurus)
- Hemoglobin subunit beta
- insulin-like growth factor binding protein 3 isoform a precursor
- insulin-like growth factor binding protein 3 isoform b precursor
- Insulin-like growth factor binding protein 3 isoform b precursor
- Insulin-like growth factor binding protein 4 precursor
- insulin-like growth factor binding protein 4 precursor
- kassinin
- microtubule-associated protein 2
- myelin basic protein
- myelin basic protein isoform 1
- myelin basic protein isoform 2
- myelin basic protein isoform 3
- myelin basic protein isoform 4
- Osteocalcin
- parathyroid hormone
- plasminogen
- Proinsulin precursor
- prolactin
- proopiomelanocortin preproprotein
- Small inducible cytokine a21 precursor
- small inducible cytokine A27 precursor
- tachykinin 1 isoform alpha precursor
- tachykinin 1 isoform beta precursor
- tachykinin 1 isoform delta precursor
- tachykinin 1 isoform gamma precursor
- Thyroglobulin
- thyroglobulin
- Substrate Specificity -- Under development
- Inhibitors -- Under development
- Pathways -- Under development
Recent News and Literature
- Unbiased Screening for Transcriptional...J Biol Chem. 2008 Dec 12;283(50):35295-304. Epub 2008 Oct 21.
- Leukocyte Elastase Inhibitor, the precursor...Biochim Biophys Acta. 2008 Jul 8.
- CHEMOTHERAPY DRUG RESPONSE IN OVARIAN...J Cell Mol Med. 2008 Jul 24.
- Gene expression analysis of a porcine...Surgery. 2008 Aug;144(2):252-8.
- [Activity of cathepsin D in the blood...Pol Arch Med Wewn. 2006 Dec;116(6):1150-4.
- Cathepsin D and carcino-embryonic...Hepatogastroenterology. 2008 Mar-Apr;55(82-83):388-93.
- Matrix metalloproteinase-9 interplays with...Glia. 2008 Jun 18;.
- Thrombin up-regulates cathepsin D which...Cancer Res. 2008 Jun 15;68(12):4666-73.
- HCCS1 overexpression induces apoptosis...Cell Death Differ. 2008 May 30;.
- Cathepsin D overexpressed by cancer...Adv Exp Med Biol. 2008;617:453-61.
- Estrogen-regulated cut-off values of pS2 and cathepsin...Adv Exp Med Biol. 2008;617:341-8.
- IFN-gamma regulation of vacuolar...J Cell Biochem. 2008 May 20;.
- 2-DE analysis of breast...Oncol Rep. 2008 May;19(5):1237-44.
- Zinc and 4-hydroxy-2-nonenal mediate...J Neurosci. 2008 Mar 19;28(12):3114-22.
- Basement membrane derived fibulin-1...Exp Biol Med (Maywood). 2008 Feb;233(2):155-62.
- American Society of Clinical...J Clin Oncol. 2007 Nov 20;25(33):5287-312. Epub 2007 Oct 22.
- A novel cell penetrating...Biochem Biophys Res Commun. 2007 Dec 14;364(2):243-9. Epub 2007 Oct 4.
- Truncation of annexin A1 is a regulatory...J Biol Chem. 2007 Dec 7;282(49):35679-86. Epub 2007 Oct 10.
- Expression of E-cadherin, beta-catenin,...Chin Med J (Engl). 2007 Sep 20;120(18):1597-605.
- The role of S100P...Cancer Res. 2007 Sep 15;67(18):8633-42.
Structural Features
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYY
GEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPC
QSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPL
IQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRD
NNRVGFAEAARL
Cross annotation in other databases
cathepsin D in:
- Gene Cards
- Diseases
- Expression
- SNP
- Drugs
- Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS

