ProteaseDB: pepsin A

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The PMAP website is a resource for the entire scientific community to foster understanding of proteolytic pathways, and to reason about proteolysis. By bringing together information of seemingly unrelated or physically disconnected information from five databases (ProteaseDB, SubstrateDB, CutDB, ProfileDB and PathwayDB) we work to bring this new and unique tool to researchers of proteolysis, cell biologists and medical professionals.

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pepsin A

Functional Attributes in Pathways

Substrates : 3 entries in CutDB for A01.001 Ext
Substrate Specificity -- Under development
Inhibitors -- Under development
Pathways -- Under development

Recent News and Literature

Reduced pepsin A processing...J Biol Chem. 2007 Nov 16;282(46):33265-74. Epub 2007 Sep 14.
Proteomic analysis revealed a...Proteomics 2004 Nov;4(11): p3343-52

Structural Features

View jmol 3D structure of 1FLH

[-] Domain Structure

MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYLDMEYFGTI

GIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTN

QIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS

LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI

VFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA

Cross annotation in other databases

pepsin A in: