cathepsin B
Functional Attributes in Pathways
-
Substrates : 60 entries in CutDB for C01.060
Ext
-
aggrecan 1 isoform 2 precursor
-
angiotensinogen preproprotein
-
beta-neoendorphin-dynorphin preproprotein
-
BH3 interacting domain death agonist
-
cathepsin B preproprotein
-
chemokine (C-C motif) ligand 20
-
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) isoform beta
-
chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
-
dynamin
-
H3 histone, family 3B
-
insulin-like growth factor 1 (somatomedin C)
-
mucolipin 1
-
myristoylated alanine-rich protein kinase C substrate
-
neurotensin/neuromedin N preproprotein
-
Osteocalcin
-
outer capsid protein mu-1
-
outer capsid protein sigma-3
-
proenkephalin
-
Proinsulin precursor
-
proopiomelanocortin preproprotein
-
renin precursor
-
Renin precursor
-
secretory leukocyte peptidase inhibitor precursor
-
Secretory leukocyte peptidase inhibitor precursor
-
small inducible cytokine A11 precursor
-
small inducible cytokine A13 precursor
-
small inducible cytokine A19 precursor
-
small inducible cytokine A21 precursor
-
small inducible cytokine A27 precursor
-
small inducible cytokine B10 precursor
-
small inducible cytokine B11 precursor
-
small inducible cytokine B14 precursor
-
small inducible cytokine B9 precursor
-
sphingosine kinase 1 isoform 1
-
thyroglobulin
-
trypsinogen
-
u-plasminogen activator precursor
-
urokinase plasminogen activator preproprotein
-
Substrate Specificity -- Under development
-
Inhibitors -- Under development
-
Pathways -- Under development
Recent News and Literature
- [DDP-sensitivity-related genes in 10 lung...Zhonghua Zhong Liu Za Zhi. 2008 Jun;30(6):418-21.
- Lysosomal cathepsin B participates...Cancer Res. 2008 Nov 15;68(22):9147-56.
- Cathepsin B is a target...Cancer Lett. 2008 Nov 10.
- Cathepsin B, cathepsin H, cathepsin...Int J Biol Markers. 2008 July-September;23(3):161-168.
- [Effects of Qushi Huayu...Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):928-33.
- Cathepsin B expression in prostate...Anticancer Res. 2008 Jul-Aug;28(4B):2271-7.
- Serum cathepsin B and plasma...Eur J Cancer Prev. 2008 Oct;17(5):438-45.
- CHEMOTHERAPY DRUG RESPONSE IN OVARIAN...J Cell Mol Med. 2008 Jul 24.
- Tumor marker utility and prognostic...BMC Cancer. 2008 Jul 10;8(1):194.
- Microarray mRNA expression analysis...Cytogenet Genome Res. 2008;121(1):10-3. Epub 2008 May 7.
- Cathepsin D overexpressed by cancer...Adv Exp Med Biol. 2008;617:453-61.
- Brevinin-2R(1) semi-selectively kills cancer...J Cell Mol Med. 2008 May-Jun;12(3):1005-22.
- Cathepsin B mediates the pH-dependent...Neoplasia. 2008 May;10(5):481-8.
- 2-DE analysis of breast...Oncol Rep. 2008 May;19(5):1237-44.
- The expression of matrix...Folia Histochem Cytobiol. 2008;46(1):57-64.
- Extrinsic pathway- and cathepsin-dependent...Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3101-12. Epub 2007 Dec 7.
- Cathepsin B expression is similar...Anticancer Res. 2007 Sep-Oct;27(5A):3135-41.
- Expression of matrix metalloproteinases-1,...Hum Pathol. 2008 Feb;39(2):217-23. Epub 2007 Oct 18.
- RNAi-mediated abrogation of cathepsin...Int J Oncol. 2007 Nov;31(5):1039-50.
- Regulation and function of aquaporin-1...Neoplasia. 2007 Sep;9(9):777-87.
Structural Features
MWQLWASLCCLLVLANARSRPSFHPVSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKL
PASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWN
FWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCG
IESEVVAGIPRTDQYWEKI
Cross annotation in other databases
cathepsin B in:
Gene Cards
- Diseases
- Expression
- SNP
- Drugs
Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS
Functional Attributes in Pathways
-
Substrates : 60 entries in CutDB for C01.060
Ext
- aggrecan 1 isoform 2 precursor
- angiotensinogen preproprotein
- beta-neoendorphin-dynorphin preproprotein
- BH3 interacting domain death agonist
- cathepsin B preproprotein
- chemokine (C-C motif) ligand 20
- chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) isoform beta
- chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
- dynamin
- H3 histone, family 3B
- insulin-like growth factor 1 (somatomedin C)
- mucolipin 1
- myristoylated alanine-rich protein kinase C substrate
- neurotensin/neuromedin N preproprotein
- Osteocalcin
- outer capsid protein mu-1
- outer capsid protein sigma-3
- proenkephalin
- Proinsulin precursor
- proopiomelanocortin preproprotein
- renin precursor
- Renin precursor
- secretory leukocyte peptidase inhibitor precursor
- Secretory leukocyte peptidase inhibitor precursor
- small inducible cytokine A11 precursor
- small inducible cytokine A13 precursor
- small inducible cytokine A19 precursor
- small inducible cytokine A21 precursor
- small inducible cytokine A27 precursor
- small inducible cytokine B10 precursor
- small inducible cytokine B11 precursor
- small inducible cytokine B14 precursor
- small inducible cytokine B9 precursor
- sphingosine kinase 1 isoform 1
- thyroglobulin
- trypsinogen
- u-plasminogen activator precursor
- urokinase plasminogen activator preproprotein
- Substrate Specificity -- Under development
- Inhibitors -- Under development
- Pathways -- Under development
Recent News and Literature
- [DDP-sensitivity-related genes in 10 lung...Zhonghua Zhong Liu Za Zhi. 2008 Jun;30(6):418-21.
- Lysosomal cathepsin B participates...Cancer Res. 2008 Nov 15;68(22):9147-56.
- Cathepsin B is a target...Cancer Lett. 2008 Nov 10.
- Cathepsin B, cathepsin H, cathepsin...Int J Biol Markers. 2008 July-September;23(3):161-168.
- [Effects of Qushi Huayu...Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):928-33.
- Cathepsin B expression in prostate...Anticancer Res. 2008 Jul-Aug;28(4B):2271-7.
- Serum cathepsin B and plasma...Eur J Cancer Prev. 2008 Oct;17(5):438-45.
- CHEMOTHERAPY DRUG RESPONSE IN OVARIAN...J Cell Mol Med. 2008 Jul 24.
- Tumor marker utility and prognostic...BMC Cancer. 2008 Jul 10;8(1):194.
- Microarray mRNA expression analysis...Cytogenet Genome Res. 2008;121(1):10-3. Epub 2008 May 7.
- Cathepsin D overexpressed by cancer...Adv Exp Med Biol. 2008;617:453-61.
- Brevinin-2R(1) semi-selectively kills cancer...J Cell Mol Med. 2008 May-Jun;12(3):1005-22.
- Cathepsin B mediates the pH-dependent...Neoplasia. 2008 May;10(5):481-8.
- 2-DE analysis of breast...Oncol Rep. 2008 May;19(5):1237-44.
- The expression of matrix...Folia Histochem Cytobiol. 2008;46(1):57-64.
- Extrinsic pathway- and cathepsin-dependent...Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3101-12. Epub 2007 Dec 7.
- Cathepsin B expression is similar...Anticancer Res. 2007 Sep-Oct;27(5A):3135-41.
- Expression of matrix metalloproteinases-1,...Hum Pathol. 2008 Feb;39(2):217-23. Epub 2007 Oct 18.
- RNAi-mediated abrogation of cathepsin...Int J Oncol. 2007 Nov;31(5):1039-50.
- Regulation and function of aquaporin-1...Neoplasia. 2007 Sep;9(9):777-87.
Structural Features
MWQLWASLCCLLVLANARSRPSFHPVSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKL
PASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWN
FWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCG
IESEVVAGIPRTDQYWEKI
Cross annotation in other databases
cathepsin B in:
- Gene Cards
- Diseases
- Expression
- SNP
- Drugs
- Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS

