cathepsin L

Functional Attributes in Pathways

  • Substrates : 14 entries in CutDB for C01.032 Ext
    • BH3 interacting domain death agonist
    • cathepsin C isoform a preproprotein
    • cathepsin L preproprotein
    • cystatin C precursor
    • elafin preproprotein
    • H3 histone, family 3B
    • heparan sulfate proteoglycan 2
    • interleukin 8 precursor
    • polypeptide [Japanese encephalitis virus].
    • procollagen, type XVIII, alpha 1
    • retinoid X receptor, alpha
    • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    • transglutaminase 3 precursor
    • urokinase plasminogen activator preproprotein
  • Substrate Specificity -- Under development
  • Inhibitors -- Under development
  • Pathways -- Under development

Recent News and Literature

  1. [DDP-sensitivity-related genes in 10 lung...Zhonghua Zhong Liu Za Zhi. 2008 Jun;30(6):418-21.
  2. CATHEPSIN L INHIBITION SUPPRESSES...Am J Physiol Cell Physiol. 2008 Oct 29.
  3. Intratumoral gene delivery of anti-cathepsin...Cancer Gene Ther. 2008 Jul 11;.
  4. Tumor marker utility and prognostic...BMC Cancer. 2008 Jul 10;8(1):194.
  5. Cathepsin D overexpressed by cancer...Adv Exp Med Biol. 2008;617:453-61.
  6. Brevinin-2R(1) semi-selectively kills cancer...J Cell Mol Med. 2008 May-Jun;12(3):1005-22.
  7. Dioxin-mediated tumor progression through...Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):186-91. Epub 2008 Jan 2.
  8. Increased expression and activity...Mol Cancer Res. 2007 Sep;5(9):899-907.
  9. Characterization of 3 oral...J Oral Maxillofac Surg. 2007 Sep;65(9):1725-33.
  10. Expression of the human...Exp Dermatol. 2007 Sep;16(9):715-23.
  11. Loss of cathepsin L activity...FASEB J. 2007 Dec;21(14):3853-65. Epub 2007 Jul 10.
  12. Cathepsin L increases invasion...Cancer Cell Int. 2007 May 8;7:8.
  13. Cigarette smoke condensate increases...Toxicol Lett. 2007 Apr 25;170(2):134-45. Epub 2007 Mar 1.
  14. Lysosomes and trivalent arsenic...J Natl Cancer Inst. 2007 Jan 3;99(1):41-52.
  15. Conditional activation of MET in differentiated...J Biol Chem. 2007 Mar 2;282(9):6812-22. Epub 2006 Dec 27.
  16. Cathepsin L affects apoptosis...Anticancer Res. 2006 Sep-Oct;26(5A):3357-64.
  17. Significance of 32-kDa cathepsin...Cancer Biother Radiopharm. 2006 Jun;21(3):217-24.
  18. Acidic extracellular pH promotes...Cancer Res. 2006 Jul 1;66(13):6699-707.
  19. Identification of protease-sensitive sites...Exp Cell Res. 2006 Jul 15;312(12):2231-7. Epub 2006 Apr 3.
  20. Antiprotease therapy in cancer:...Expert Opin Biol Ther. 2006 Mar;6(3):257-79.

Structural Features

[-] Domain Structure

Homologs

Sequence

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAF

GDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLIS

LSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA

TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRN

HCGIASAASYPTV

Cross annotation in other databases

cathepsin L in: