ProteaseDB: MMP26

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The PMAP website is a resource for the entire scientific community to foster understanding of proteolytic pathways, and to reason about proteolysis. By bringing together information of seemingly unrelated or physically disconnected information from five databases (ProteaseDB, SubstrateDB, CutDB, ProfileDB and PathwayDB) we work to bring this new and unique tool to researchers of proteolysis, cell biologists and medical professionals.

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MMP26

Functional Attributes in Pathways

Substrates : 20 entries in CutDB for M10.029 Ext
Substrate Specificity -- Under development
Inhibitors -- Under development
Pathways -- Under development

Recent News and Literature

Additional MDA-MB-231 breast cancer...J Cell Physiol. 2008 Aug;216(2):480-5.
Expression of MMP-9, MMP-10...J Cutan Pathol. 2007 Dec;34(12):889-98.
Increased expression of matrix...Mod Pathol. 2007 Nov;20(11):1128-40. Epub 2007 Sep 14.
Calcium regulates tertiary structure...Biochem J. 2007 Apr 1;403(1):31-42.
Expression of matrix metalloproteinase-26...Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1794-800.
MMP-21 is expressed by macrophages...Exp Dermatol. 2006 Oct;15(10):775-83.
Peaking of MMP-26 and TIMP-4...Cell Res. 2006 Sep;16(9):741.
Coordinated peak expression of MMP-26...Cell Res. 2006 Sep;16(9):750-8.
Oxytocin induces proliferation and migration...Mol Cancer Res. 2006 Jun;4(6):351-9.
Matrix metalloproteinases 21 and 26 are differentially...Tumour Biol. 2006;27(3):133-41. Epub 2006 Apr 20.
Matrix metalloproteinase 26 proteolysis...Cancer Res 2006 Mar 1;66(5): p2716-24
Matrilysin-2 (matrix metalloproteinase-26) is upregulated...J Invest Dermatol 2005 Apr;124(4): p849-56
Matrix metalloproteinase-26 is associated...Cancer Res 2004 Dec 1;64(23): p8657-65
Matrix metalloproteinase-26 (matrilysin-2) expression...Gynecol Oncol 2004 Sep;94(3): p661-70
MRP-1/CD9 gene transduction downregulates...Oncogene 2004 Sep 30;23(45): p7475-83
Association of matrilysin-2 (MMP-26)...Carcinogenesis 2004 Dec;25(12): p2353-60
Differential expression of three...Dig Dis Sci 2004 Apr;49(4): p653-61
Endometase/matrilysin-2 in human breast...Cancer Res 2004 Jan 15;64(2): p590-8
Differential expression of matrilysin-1...J Pathol 2004 Jan;202(1): p14-22
Expression of matrix metalloproteinase-26...Gynecol Oncol 2003 Jun;89(3): p453-9

Structural Features

Structure has not yet been determined for this protein.

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[-] Domain Structure

MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQP

HCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHED

GWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQL

SADDIQRIQHLYGEKCSSDIP

Cross annotation in other databases

MMP26 in: