ADAM17
Functional Attributes in Pathways
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Substrates : 73 entries in CutDB for M12.217
Ext
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activated leukocyte cell adhesion molecule
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amphiregulin preproprotein
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amyloid beta A4 protein precursor, isoform a
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angiotensin I converting enzyme 2 precursor
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betacellulin
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betacellulin, epidermal growth factor family member
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CD40 ligand
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CD44 antigen isoform 1 precursor
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chemokine (C-X-C motif) ligand 16
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chemokine (C-X3-C motif) ligand 1
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delta-like 1
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desmoglein 2 preproprotein
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epidermal growth factor (beta-urogastrone)
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epiregulin
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epiregulin preproprotein
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epithelial cell adhesion molecule precursor
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glycoprotein 1b, alpha polypeptide
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glycoprotein 5 (platelet)
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growth hormone receptor precursor
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heparin-binding EGF-like growth factor
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intercellular adhesion molecule 1 precursor
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interleukin 15 receptor, alpha chain isoform 1
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interleukin 6 receptor isoform 1 precursor
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kit ligand
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klotho
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lymphocyte-activation gene 3
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mucin 1 isoform 1 precursor
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myelin basic protein
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nerve growth factor receptor (TNFR superfamily, member 16)
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nerve growth factor receptor precursor
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neuregulin 1 isoform GGF
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neuregulin 1 isoform GGF2
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neuregulin 1 isoform HRG-alpha
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neuregulin 1 isoform HRG-beta1
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neuregulin 1 isoform HRG-beta2
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neuregulin 1 isoform HRG-beta3
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neuregulin 1 isoform HRG-gamma
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neuregulin 1 isoform ndf43
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neuregulin 1 isoform SMDF
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neuronal pentraxin receptor
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Notch1 preproprotein
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peptidyl dipeptidase A (recombinant somatic isoform) (human)
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peptidyl dipeptidase A (somatic isoform) (Homo sapiens)
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peptidyl dipeptidase A (testicular isoform) (Oryctolagus cuniculus)
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platelet glycoprotein Ib alpha polypeptide precursor
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prion protein preproprotein
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proinsulin precursor
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reticulon 4 receptor precursor
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selectin L
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transforming growth factor alpha
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transforming growth factor, alpha
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transmembrane protein with EGF-like and two follistatin-like domains 2
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tumor necrosis factor (ligand) superfamily, member 11
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tumor necrosis factor (ligand) superfamily, member 8
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Tumor necrosis factor alpha
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tumor necrosis factor receptor 1 precursor
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tumor necrosis factor receptor 2 precursor
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v-erb-a erythroblastic leukemia viral oncogene homolog 4
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vascular cell adhesion molecule 1 isoform b precursor
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vvascular cell adhesion molecule 1 isoform a precursor
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Substrate Specificity -- Under development
-
Inhibitors -- Under development
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Pathways -- Under development
Recent News and Literature
We currently do not have custom news for this protein.
Structural Features
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFK
LYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK
DKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQ
FSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEAD
LVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGN
AEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGK
CEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPV
TRSEKAASFKLQRQNRVDSKETEC
Cross annotation in other databases
ADAM17 in:
Gene Cards
- Diseases
- Expression
- SNP
- Drugs
Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS
Functional Attributes in Pathways
-
Substrates : 73 entries in CutDB for M12.217
Ext
- activated leukocyte cell adhesion molecule
- amphiregulin preproprotein
- amyloid beta A4 protein precursor, isoform a
- angiotensin I converting enzyme 2 precursor
- betacellulin
- betacellulin, epidermal growth factor family member
- CD40 ligand
- CD44 antigen isoform 1 precursor
- chemokine (C-X-C motif) ligand 16
- chemokine (C-X3-C motif) ligand 1
- delta-like 1
- desmoglein 2 preproprotein
- epidermal growth factor (beta-urogastrone)
- epiregulin
- epiregulin preproprotein
- epithelial cell adhesion molecule precursor
- glycoprotein 1b, alpha polypeptide
- glycoprotein 5 (platelet)
- growth hormone receptor precursor
- heparin-binding EGF-like growth factor
- intercellular adhesion molecule 1 precursor
- interleukin 15 receptor, alpha chain isoform 1
- interleukin 6 receptor isoform 1 precursor
- kit ligand
- klotho
- lymphocyte-activation gene 3
- mucin 1 isoform 1 precursor
- myelin basic protein
- nerve growth factor receptor (TNFR superfamily, member 16)
- nerve growth factor receptor precursor
- neuregulin 1 isoform GGF
- neuregulin 1 isoform GGF2
- neuregulin 1 isoform HRG-alpha
- neuregulin 1 isoform HRG-beta1
- neuregulin 1 isoform HRG-beta2
- neuregulin 1 isoform HRG-beta3
- neuregulin 1 isoform HRG-gamma
- neuregulin 1 isoform ndf43
- neuregulin 1 isoform SMDF
- neuronal pentraxin receptor
- Notch1 preproprotein
- peptidyl dipeptidase A (recombinant somatic isoform) (human)
- peptidyl dipeptidase A (somatic isoform) (Homo sapiens)
- peptidyl dipeptidase A (testicular isoform) (Oryctolagus cuniculus)
- platelet glycoprotein Ib alpha polypeptide precursor
- prion protein preproprotein
- proinsulin precursor
- reticulon 4 receptor precursor
- selectin L
- transforming growth factor alpha
- transforming growth factor, alpha
- transmembrane protein with EGF-like and two follistatin-like domains 2
- tumor necrosis factor (ligand) superfamily, member 11
- tumor necrosis factor (ligand) superfamily, member 8
- Tumor necrosis factor alpha
- tumor necrosis factor receptor 1 precursor
- tumor necrosis factor receptor 2 precursor
- v-erb-a erythroblastic leukemia viral oncogene homolog 4
- vascular cell adhesion molecule 1 isoform b precursor
- vvascular cell adhesion molecule 1 isoform a precursor
- Substrate Specificity -- Under development
- Inhibitors -- Under development
- Pathways -- Under development
Recent News and Literature
Structural Features
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFK
LYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK
DKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQ
FSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEAD
LVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGN
AEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGK
CEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPV
TRSEKAASFKLQRQNRVDSKETEC
Cross annotation in other databases
ADAM17 in:
- Gene Cards
- Diseases
- Expression
- SNP
- Drugs
- Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS

