ProfileDB: The PMAP protease specificity database and tools
Steps to predict substrates and cleavage sites
1. Create Model:
2. Predict substrates and substrate cleavage:
3. Examples:
| Proteome-wide substrate predictions | Protease specificity models* | Download raw profiling data |
|---|---|---|
| MMP-2 | MMP-2 | MMP-2 |
| MMP-9 | MMP-9 | MMP-9 |
| MMP-14 | MMP-14 | MMP-14 |
| MMP-15 | MMP-15 | MMP-15 |
| MMP-16 | MMP-16 | MMP-16 |
| MMP-24 | MMP-24 | MMP-24 |
| MMP-25 | MMP-25 | MMP-25 |
*Save the model on your computer if you want to do your own predictions of substrates and cleavage sites.
Searching ProfileDB
- Search for specificity data in ProfileDB or
- View all records for phage and peptide library display.
Submit data to ProfileDB
- Please register to submit data.
- What is the benefit of submitting my data?
Benefit of contributing your data to ProfileDB:
- You will be able to access your data easily.
- You will be able to develop a specificity model (PWM) for your protease.
- You will be able to predict substrates and cleavage sites in the human proteome or any protein sequence.
- Your data will be easily reachable by the community.
© The PMAP Web Site is managed by The Center on Proteolytic Pathways at the Burnham Institute for Medical Research through a grant from the NIH Roadmap.
Copyright 2008. All rights reserved.
The Burnham Institute for Medical Research 10901 N. Torrey Pines Rd., La Jolla, CA 92037.
With problems, comments, or suggestions please contact: pmap_info@burnham.org