coagulation factor VIIa

Structure 2BZ6

Model pmap.18069


Structures

Structure Region Pdb Id Title Resolution Technique
1DAN complex of active site inhibited human blood coagulation factor viia with human recombinant soluble tissue factor 2 x-ray
1QFK structure of human factor viia and its implications for the triggering of blood coagulation 2.8 x-ray
1DVA crystal structure of the complex between the peptide exosite inhibitor e-76 and coagulation factor viia 3 x-ray
1FAK human tissue factor complexed with coagulation factor viia inhibited with a bpti-mutant 2.1 x-ray
1JBU coagulation factor vii zymogen (egf2/protease) in complex with inhibitory exosite peptide a-183 2 x-ray
1CVW crystal structure of active site-inhibited human coagulation factor viia (des-gla) 2.28 x-ray
1KLI cofactor-and substrate-assisted activation of factor viia 1.69 x-ray
1KLJ crystal structure of uninhibited factor viia 2.44 x-ray
1J9C crystal structure of tissue factor-factor viia complex 2.9 x-ray
1W0Y tf7a_3771 complex 2.5 x-ray
1O5D dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa) 2.05 x-ray
1W2K tf7a_4380 complex 3 x-ray
1Z6J crystal structure of a ternary complex of factor viia/tissue factor/pyrazinone inhibitor 2 x-ray
1WQV human factor viia-tissue factor complexed with propylsulfonamide-d-thr-met-p-aminobenzamidine 2.5 x-ray
1W7X factor7 - 413 complex 1.8 x-ray
1W8B factor7 - 413 complex 3 x-ray
1YGC short factor viia with a small molecule inhibitor 2 x-ray
1WTG human factor viia-tissue factor complexed with ethylsulfonamide-d-biphenylalanine-gln-p-aminobenzamidine 2.2 x-ray
1WUN human factor viia-tissue factor complexed with ethylsulfonamide-d-trp-gln-p-aminobenzamidine 2.4 x-ray
1WV7 human factor viia-tissue factor complexed with ethylsulfonamide-d-5-propoxy-trp-gln-p-aminobenzamidine 2.7 x-ray
1WSS human factor viia-tissue factor in complex with peprid mimetic inhibitor that has two charge groups in p2 and p4 2.6 x-ray
2B7D factor viia inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in a baboon thrombosis model 2.24 x-ray
2F9B discovery of novel heterocyclic factor viia inhibitors 2.54 x-ray
2FLB discovery of a novel hydroxy pyrazole based factor ixa inhibitor 1.95 x-ray
2BZ6 orally available factor7a inhibitor 1.6 x-ray


Models

Model Region Name Title Template Alignment % Identity Alignment Expectation Value
14817 Chain L, Dissecting And Designing Inhibitor Selectivity Determinants At The S1 Site Using An Artificial Ala190 Protease (Ala190 Upa) 1o5dl 100 2e-91