| Structure Region |
Pdb Id |
Title |
Resolution |
Technique |
 |
1DOJ
| crystal structure of human alpha-thrombin*rwj-51438 complex at 1.7 a |
1.7 |
x-ray |
 |
1HAG
| |
2 |
|
 |
1XM1
| nonbasic thrombin inhibitor complex |
2.3 |
x-ray |
 |
1JWT
| crystal structure of thrombin in complex with a novel bicyclic lactam inhibitor |
2.5 |
x-ray |
 |
1NU9
| staphylocoagulase-prethrombin-2 complex |
2.2 |
x-ray |
 |
1D9I
| structure of thrombin complexed with selective non- electophilic inhibitors having cyclohexyl moieties at p1 |
2.3 |
x-ray |
 |
1EOJ
| design of p1' and p3' residues of trivalent thrombin inhibitors and their crystal structures |
2.1 |
x-ray |
 |
1EOL
| design of p1' and p3' residues of trivalent thrombin inhibitors and their crystal structures |
2.1 |
x-ray |
 |
1NM6
| thrombin in complex with selective macrocyclic inhibitor at 1.8a |
1.8 |
x-ray |
 |
1NT1
| thrombin in complex with selective macrocyclic inhibitor |
2 |
x-ray |
 |
1TA2
| crystal structure of thrombin in complex with compound 1 |
2.3 |
x-ray |
 |
1TA6
| crystal structure of thrombin in complex with compound 14b |
1.9 |
x-ray |
 |
1ZRB
| thrombin in complex with an azafluorenyl inhibitor 23b |
1.9 |
x-ray |
 |
1Z71
| thrombin and p2 pyridine n-oxide inhibitor complex structure |
1.8 |
x-ray |
 |
1ZGI
| thrombin in complex with an oxazolopyridine inhibitor 21 |
2.2 |
x-ray |
 |
1ZGV
| thrombin in complex with an oxazolopyridine inhibitor 2 |
2.2 |
x-ray |
 |
1SL3
| crystal structue of thrombin in complex with a potent p1 heterocycle-aryl based inhibitor |
1.81 |
x-ray |
 |
1D6W
| structure of thrombin complexed with selective non- electrophilic inhibitors having cyclohexyl moieties at p1 |
2 |
x-ray |
 |
1G37
| crystal structure of human alpha-thrombin complexed with bch-10556 and exosite-directed peptide |
2 |
x-ray |
 |
1MH0
| crystal structure of the anticoagulant slow form of thrombin |
2.8 |
x-ray |
 |
1DM4
| ser195ala mutant of human thrombin complexed with fibrinopeptide a (7-16) |
2.5 |
x-ray |
 |
1JMO
| crystal structure of the heparin cofactor ii-s195a thrombin complex |
2.2 |
x-ray |
 |
1ABI
| |
2.3 |
|
 |
1ABJ
| |
2.4 |
|
 |
1DWB
| |
3.16 |
|
 |
1DWC
| |
3 |
|
 |
1DWD
| |
3 |
|
 |
1DWE
| |
3 |
|
 |
1FPH
| |
2.5 |
|
 |
1HAH
| |
2.3 |
|
 |
1HAI
| |
2.4 |
|
 |
1HDT
| |
2.6 |
x-ray |
 |
1HGT
| |
2.2 |
|
 |
1HLT
| |
3 |
|
 |
1HUT
| |
2.9 |
|
 |
1IHS
| |
2 |
|
 |
1IHT
| |
2.1 |
|
 |
1NRN
| |
3.1 |
|
 |
1NRO
| |
3.1 |
|
 |
1NRP
| |
3 |
|
 |
1NRQ
| |
3.5 |
|
 |
1NRR
| |
2.4 |
|
 |
1NRS
| |
2.4 |
|
 |
1PPB
| |
1.92 |
|
 |
1THR
| |
2.3 |
|
 |
1THS
| |
2.2 |
|
 |
1TMT
| |
2.2 |
|
 |
1TMU
| |
2.5 |
|
 |
2HGT
| |
2.2 |
|
 |
2HPP
| |
3.3 |
|
 |
2HPQ
| |
3.3 |
|
 |
4HTC
| |
2.3 |
|
 |
1A2C
| structure of thrombin inhibited by aeruginosin298-a from a blue-green alga |
2.1 |
x-ray |
 |
1A3B
| complex of human alpha-thrombin with the bifunctional boronate inhibitor borolog1 |
1.8 |
x-ray |
 |
1A3E
| complex of human alpha-thrombin with the bifunctional boronate inhibitor borolog2 |
1.85 |
x-ray |
 |
1A46
| thrombin complexed with hirugen and a beta-strand mimetic inhibitor |
2.12 |
x-ray |
 |
1A4W
| crystal structures of thrombin with thiazole-containing inhibitors: probes of the s1' binding site |
1.8 |
x-ray |
 |
1A5G
| human thrombin complexed with novel synthetic peptide mimetic inhibitor and hirugen |
2.06 |
x-ray |
 |
1A61
| thrombin complexed with a beta-mimetic thiazole-containing inhibitor |
2.2 |
x-ray |
 |
1AD8
| complex of thrombin with and inhibitor containing a novel p1 moiety |
2 |
x-ray |
 |
1AE8
| human alpha-thrombin inhibition by eoc-d-phe-pro-azalys-onp |
2 |
x-ray |
 |
1AFE
| human alpha-thrombin inhibition by cbz-pro-azalys-onp |
2 |
x-ray |
 |
1AI8
| human alpha-thrombin ternary complex with the exosite inhibitor hirugen and active site inhibitor phch2oco-d-dpa-pro-borompg |
1.85 |
x-ray |
 |
1AIX
| human alpha-thrombin ternary complex with exosite inhibitor hirugen and active site inhibitor phch2oco-d-dpa-pro-boroval |
2.1 |
x-ray |
 |
1B5G
| human thrombin complexed with novel synthetic peptide mimetic inhibitor and hirugen |
2.07 |
x-ray |
 |
1BMM
| human alpha-thrombin complexed with [s-(r*,r*)]-4- [(aminoiminomethyl)amino]-n-[[1-[3-hydroxy-2-[(2- naphthalenylsulfonyl)amino]-1-oxopropyl]-2-pyrrolidinyl] methyl]butanamide (bms-186282) |
2.6 |
x-ray |
 |
1BMN
| human alpha-thrombin complexed with [s-(r*,r*)]-1- (aminoiminomethyl)-n-[[1-[n-[(2-naphthalenylsulfonyl)-l- seryl]-pyrrolidinyl]methyl]-3-piperidenecarboxamide (bms-189090) |
2.8 |
x-ray |
 |
1HAO
| complex of human alpha-thrombin with a 15mer oligonucleotide ggttggtgtggttgg (based on nmr model of dna) |
2.8 |
x-ray |
 |
1HAP
| complex of human alpha-thrombin with a 15mer oligonucleotide ggttggtgtggttgg (based on x-ray model of dna) |
2.8 |
x-ray |
 |
1HBT
| human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor |
2 |
x-ray |
 |
1HXF
| human thrombin complex with hirudin variant |
2.1 |
x-ray |
 |
1LHC
| human alpha-thrombin complexed with ac-(d)phe-pro-boroarg-oh |
1.95 |
x-ray |
 |
1LHD
| human alpha-thrombin complexed with ac-(d)phe-pro-borolys-oh |
2.35 |
x-ray |
 |
1LHE
| human alpha-thrombin complexed with ac-(d)phe-pro-boro-n-butyl-amidino-glycine-oh |
2.25 |
x-ray |
 |
1LHF
| human alpha-thrombin complexed with ac-(d)phe-pro-boro-homolys-oh |
2.4 |
x-ray |
 |
1LHG
| human alpha-thrombin complexed with ac-(d)phe-pro-boroornithine-oh |
2.25 |
x-ray |
 |
1TBZ
| human thrombin with active site n-methyl-d phenylalanyl-n- [5-(aminoiminomethyl)amino]-1-{{benzothiazolyl)carbonyl] butyl]-l-prolinamide trifluroacetate and exosite-hirugen |
2.3 |
x-ray |
 |
1TOM
| alpha-thrombin complexed with hirugen |
1.8 |
x-ray |
 |
1UMA
| alpha-thrombin (hirugen) complexed with na-(n,n-dimethylcarbamoyl)-alpha-azalysine |
2 |
x-ray |
 |
1UVS
| bovine thrombin--bm51.1011 complex |
2.8 |
x-ray |
 |
5GDS
| hirunorms are true hirudin mimetics. the crystal structure of human alpha-thrombin:hirunorm v complex |
2.1 |
x-ray |
 |
1AWF
| novel covalent thrombin inhibitor from plant extract |
2.2 |
x-ray |
 |
1AWH
| novel covalent thrombin inhibitor from plant extract |
3 |
x-ray |
 |
1BCU
| alpha-thrombin complexed with hirugen and proflavin |
2 |
x-ray |
 |
1AY6
| thrombin inhibitor from theonalla, cyclotheanamide-based macrocyclic tripeptide motif |
1.8 |
x-ray |
 |
8KME
| crystal structure of human alpha-thrombin inhibited with sel2770. |
2.1 |
x-ray |
 |
1BA8
| thrombin inhibitor with a rigid tripeptidyl aldehydes |
1.8 |
x-ray |
 |
1BB0
| thrombin inhibitors with rigid tripeptidyl aldehydes |
2.1 |
x-ray |
 |
1CA8
| thrombin inhibitors with rigid tripeptidyl aldehydes |
2.1 |
x-ray |
 |
4THN
| the crystal structure of alpha-thrombin-hirunorm iv complex reveals a novel specificity site recognition mode. |
2.5 |
x-ray |
 |
1QBV
| crystal structure of thrombin complexed with an guanidine- mimetic inhibitor |
1.8 |
x-ray |
 |
1QHR
| novel covalent active site thrombin inhibitors |
2.2 |
x-ray |
 |
1QJ1
| novel covalent active site thrombin inhibitors |
2 |
x-ray |
 |
1D3P
| crystal structure of human aplha-thrombin in complex with benzo[b]thiophene inhibitor 3 |
2.1 |
x-ray |
 |
1D3Q
| crystal structure of human alpha thrombin in complex with benzo[b]thiophene inhibitor 2 |
2.9 |
x-ray |
 |
1C4U
| selective non electrophilic thrombin inhibitors with cyclohexyl moieties. |
2.1 |
x-ray |
 |
1C4V
| selective non electrophilic thrombin inhibitors with cyclohexyl moieties. |
2.1 |
x-ray |
 |
1C4Y
| selective non-electrophilic thrombin inhibitors |
2.7 |
x-ray |
